Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants

• Main Authors: Jacqz-Aigrain, Evelyne, Leroux, Stéphanie, Thomson, Alison H., Allegaert, Karel, Capparelli, Edmund V., Biran, Valérie, Simon, Nicolas, Meibohm, Bernd, Lo, Yoke Lin, Marques, Remedios, Peris, José-Esteban, Lutsar, Irja, Saito, Jumpei, Nakamura, Hidefumi, van den Anker, Johannes N., Sharland, Mike, Zhao, Wei
• Format: Article
• Published: Oxford University Press 2019
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/24098/; https://doi.org/10.1093/jac/dkz158

OBJECTIVES: In the absence of consensus, the present meta-analysis was performed to determine an optimal dosing regimen of vancomycin for neonates. METHODS: A 'meta-model' with 4894 concentrations from 1631 neonates was built using NONMEM, and Monte Carlo simulations were performed to desi...