The 4717C > G polymorphism in periplakin modulates sensitivity to EGFR inhibitors

• Main Authors: Lee, Hui Mei, Kelly, Gregory Michael, Zainal, Nur Syafinaz, Yee, Pei San, Fadlullah, Muhammad Zaki Hidayatullah, Lee, Bernard Kok Bang, Gan, Chai Phei, Patel, Vyomesh, Cheong, Sok Ching
• Format: Article
• Language: English
• Published: Nature Research 2019
• Subjects: R Medicine; RK Dentistry
• Online Access: http://eprints.um.edu.my/23887/1/s41598-019-38742-0.pdf; http://eprints.um.edu.my/23887/; https://www.nature.com/articles/s41598-019-38742-0.pdf

The use of EGFR inhibitors on oral squamous cell carcinoma (OSCC) as monotherapy yielded modest clinical outcomes and therefore would benefit from biomarkers that could predict which patient subsets are likely to respond. Here, we determined the efficacy of erlotinib in OSCC cell lines, and by compa...