Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance

• Main Authors: Zainal, Nur Syafinaz, Lee, Bernard Kok Bang, Wong, Zheng Wei, Chin, Iuan Sheau, Yee, Pei San, Gan, Chai Phei, Mun, Kein Seong, Rahman, Zainal Ariff Abdul, Silvio Gutkind, J., Patel, Vyomesh, Cheong, Sok Ching
• Format: Article
• Published: Chinese Anti-cancer Association 2019
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/22928/; https://doi.org/10.20892/j.issn.2095-3941.2018.0257

Objective: Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma (OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. Hence...