Collagen Induces a More Proliferative, Migratory and Chemoresistant Phenotype in Head and Neck Cancer via DDR1

• Main Authors: Lai, Sook Ling, Tan, May Leng, Hollows, Robert J., Robinson, Max, Ibrahim, Maha, Margielewska, Sandra, Parkinson, E. Kenneth, Ramanathan, Anand, Zain, R.B., Mehanna, Hisham, Spruce, Rachel J., Wei, Wenbin, Chung, Ivy, Murray, Paul G., Yap, Lee Fah, Paterson, Ian Charles
• Format: Article
• Language: English
• Published: MDPI 2019
• Subjects: R Medicine; RC0254 Neoplasms. Tumors. Oncology (including Cancer); RK Dentistry; Practice of dentistry. Dental economics
• Online Access: http://eprints.um.edu.my/23886/1/cancers-11-01766%20%284%29.pdf; http://eprints.um.edu.my/23886/; https://www.mdpi.com/2072-6694/11/11/1766/htm

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and includes squamous cell carcinomas of the oropharynx and oral cavity. Patient prognosis has remained poor for decades and molecular targeted therapies are not in routine use. Here we showed that the overall ex...