Dengue protease inhibition activity of selected malaysian medicinal herbs

• Main Authors: Salleh, H.M., Chong, Soon Lim, Othman, Rozana, Hazni, Hazrina, Ahmad, Khadher, Mohd Yusoff, Mohd Yakub @ Zulkifli, Fauzi, Nurulwahidah, Wahab, Habibah A., Liew, Sook Yee, Awang, Khalijah
• Format: Article
• Published: Malaysian Society of Parasitology and Tropical Medicine 2019
• Subjects: BP Islam. Bahaism. Theosophy, etc; QD Chemistry; R Medicine
• Online Access: http://eprints.um.edu.my/23552/; http://msptm.org/files/Vol36No2/357-366-Awang-K.pdf

Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 µg/mL with IC50 value of 0.30 ± 0.16 µg/mL. © 2019, Malaysian Society for Parasitology. All rights reserved.