Acute and 28-day sub-acute intravenous toxicity studies of 1’-S-1′-acetoxychavicol acetate in rats

• Main Authors: Abdalla, Yasir Osman Ali, Nyamathulla, Shaik, Shamsuddin, Noorasyikin, Arshad, Norhafiza Mohd, Mun, Kein Seong, Awang, Khalijah, Nagoor, Noor Hasima
• Format: Article
• Published: Elsevier 2018
• Subjects: Q Science (General); QD Chemistry; QH Natural history; R Medicine
• Online Access: http://eprints.um.edu.my/22751/; https://doi.org/10.1016/j.taap.2018.08.014

1′-S-1′-acetoxychavicol acetate (ACA) has been previously reported to reduce tumor volume in nude mice, at an effective dose of 1.56 mg/kg body weight. However, the detailed toxicological profile for ACA has not yet been performed. Herein, we investigated the toxicity of intravenous administration o...