The apoptotic effect of 1’S-1’-Acetoxychavicol Acetate (ACA) enhanced by inhibition of non-canonical autophagy in human non-small cell lung cancer cells

• Main Authors: Sok, S.P.M., Arshad, Norhafiza Mohd, Azmi, M.N., Awang, Khalijah, Ozpolat, B., Nagoor, Noor Hasima
• Format: Article
• Language: English
• Published: Public Library of Science 2017
• Subjects: Q Science (General); QD Chemistry; QH Natural history
• Online Access: http://eprints.um.edu.my/19019/1/The_apoptotic_effect_of_1%E2%80%B2S-1%E2%80%B2-Acetoxychavicol_Acetate_%28ACA%29_enhanced_by_inhibition_of_non-canonical_autophagy_in_human_non-small_cell_lung_cancer_cells.pdf; http://eprints.um.edu.my/19019/; http://dx.doi.org/10.1371/journal.pone.0171329

Autophagy plays a role in deciding the fate of cells by inducing either survival or death. 1’S-1-acetoxychavicol acetate (ACA) is a phenylpropanoid isolated from rhizomes of Alpinia conchigera and has been reported previously on its apoptotic effects on various cancers. However, the effect of ACA on...