Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy

• Main Authors: Chambre, Laura, Saw, Wen Shang, Ekineker, Gülçin, Kiew, Lik Voon, Chong, Wu Yi, Lee, Hong Boon, Chung, Lip Yong, Bretonnière, Yann, Dumoulin, Fabienne, Sanyal, Amitav
• Format: Article
• Published: American Chemical Society 2018
• Subjects: QD Chemistry; R Medicine; TP Chemical technology
• Online Access: http://eprints.um.edu.my/22286/; https://doi.org/10.1021/acs.bioconjchem.8b00787

Photosensitizing nanogels were obtained through a surfactant-free single-step protocol by using a porphyrin-based cross-linker for stabilizing self-assembled nanosized aggregates of thermoresponsive copolymers. Nanogels with varying amounts of porphyrin retained the singlet oxygen generation ability...