Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy
Photosensitizing nanogels were obtained through a surfactant-free single-step protocol by using a porphyrin-based cross-linker for stabilizing self-assembled nanosized aggregates of thermoresponsive copolymers. Nanogels with varying amounts of porphyrin retained the singlet oxygen generation ability...
Saved in:
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Published: |
American Chemical Society
2018
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/22286/ https://doi.org/10.1021/acs.bioconjchem.8b00787 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.um.eprints.22286 |
---|---|
record_format |
eprints |
spelling |
my.um.eprints.222862019-09-11T03:22:49Z http://eprints.um.edu.my/22286/ Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy Chambre, Laura Saw, Wen Shang Ekineker, Gülçin Kiew, Lik Voon Chong, Wu Yi Lee, Hong Boon Chung, Lip Yong Bretonnière, Yann Dumoulin, Fabienne Sanyal, Amitav QD Chemistry R Medicine TP Chemical technology Photosensitizing nanogels were obtained through a surfactant-free single-step protocol by using a porphyrin-based cross-linker for stabilizing self-assembled nanosized aggregates of thermoresponsive copolymers. Nanogels with varying amounts of porphyrin retained the singlet oxygen generation ability of the porphyrin core and were also capable of inducing temperature increase upon irradiation at 635 nm. Photoinduced killing efficiency was tested against three cell lines: human breast adenocarcinoma (MDA-MB-231 and MCF7) and pancreatic adenocarcinoma (AsPC-1) cells, and a predominant photodynamic mechanism at 450 nm and a mixed photodynamic and photothermal effect at 635 nm was observed. This innovative access to photosensitizing nanogels is a proof of concept, and opens new perspectives toward the preparation of optimized nanophotosensitizers. American Chemical Society 2018 Article PeerReviewed Chambre, Laura and Saw, Wen Shang and Ekineker, Gülçin and Kiew, Lik Voon and Chong, Wu Yi and Lee, Hong Boon and Chung, Lip Yong and Bretonnière, Yann and Dumoulin, Fabienne and Sanyal, Amitav (2018) Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy. Bioconjugate Chemistry, 29 (12). pp. 4149-4159. ISSN 1043-1802 https://doi.org/10.1021/acs.bioconjchem.8b00787 doi:10.1021/acs.bioconjchem.8b00787 |
institution |
Universiti Malaya |
building |
UM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaya |
content_source |
UM Research Repository |
url_provider |
http://eprints.um.edu.my/ |
topic |
QD Chemistry R Medicine TP Chemical technology |
spellingShingle |
QD Chemistry R Medicine TP Chemical technology Chambre, Laura Saw, Wen Shang Ekineker, Gülçin Kiew, Lik Voon Chong, Wu Yi Lee, Hong Boon Chung, Lip Yong Bretonnière, Yann Dumoulin, Fabienne Sanyal, Amitav Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy |
description |
Photosensitizing nanogels were obtained through a surfactant-free single-step protocol by using a porphyrin-based cross-linker for stabilizing self-assembled nanosized aggregates of thermoresponsive copolymers. Nanogels with varying amounts of porphyrin retained the singlet oxygen generation ability of the porphyrin core and were also capable of inducing temperature increase upon irradiation at 635 nm. Photoinduced killing efficiency was tested against three cell lines: human breast adenocarcinoma (MDA-MB-231 and MCF7) and pancreatic adenocarcinoma (AsPC-1) cells, and a predominant photodynamic mechanism at 450 nm and a mixed photodynamic and photothermal effect at 635 nm was observed. This innovative access to photosensitizing nanogels is a proof of concept, and opens new perspectives toward the preparation of optimized nanophotosensitizers. |
format |
Article |
author |
Chambre, Laura Saw, Wen Shang Ekineker, Gülçin Kiew, Lik Voon Chong, Wu Yi Lee, Hong Boon Chung, Lip Yong Bretonnière, Yann Dumoulin, Fabienne Sanyal, Amitav |
author_facet |
Chambre, Laura Saw, Wen Shang Ekineker, Gülçin Kiew, Lik Voon Chong, Wu Yi Lee, Hong Boon Chung, Lip Yong Bretonnière, Yann Dumoulin, Fabienne Sanyal, Amitav |
author_sort |
Chambre, Laura |
title |
Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy |
title_short |
Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy |
title_full |
Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy |
title_fullStr |
Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy |
title_full_unstemmed |
Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy |
title_sort |
surfactant-free direct access to porphyrin-cross-linked nanogels for photodynamic and photothermal therapy |
publisher |
American Chemical Society |
publishDate |
2018 |
url |
http://eprints.um.edu.my/22286/ https://doi.org/10.1021/acs.bioconjchem.8b00787 |
_version_ |
1646210197628125184 |
score |
13.160551 |