Biophysical and computational characterization of vandetanib–lysozyme interaction

• Main Authors: Kabir, Md Zahirul, Hamzah, Nur Aziean, Ghani, Hamidah, Mohamad, Saharuddin, Alias, Zazali, Tayyab, Saad
• Format: Article
• Published: Elsevier 2018
• Subjects: Q Science (General); QH Natural history
• Online Access: http://eprints.um.edu.my/21726/; https://doi.org/10.1016/j.saa.2017.08.051

Interaction of an anticancer drug, vandetanib (VDB) with a ligand transporter, lysozyme (LYZ) was explored using multispectroscopic techniques, such as fluorescence, absorption and circular dichroism along with computational analysis. Fluorescence data and absorption results confirmed VDB–LYZ comple...