Cover Image

Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology

A statistical approach with D-optimal design was used to optimize the process parameters for polycaprolactone (PCL) synthesis. The variables selected were temperature (50°C-110°C), time (1-7 h), mixing speed (50-500 rpm) and monomer/solvent ratio (1:1-1:6). Molecular weight was chosen as response an...

Full description

Saved in:
Bibliographic Details
Main Authors: Pakalapati, Harshini, Arumugasamy, Senthil Kumar, Jewaratnam, Jegalakshimi, Wong, Yong Jie, Khalid, Mohammad
Format: Article
Published: Wiley 2018
Subjects:
TP Chemical technology
Online Access:http://eprints.um.edu.my/21049/
https://doi.org/10.1002/bip.23240
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.21049
record_format eprints
spelling my.um.eprints.210492019-04-24T03:46:34Z http://eprints.um.edu.my/21049/ Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology Pakalapati, Harshini Arumugasamy, Senthil Kumar Jewaratnam, Jegalakshimi Wong, Yong Jie Khalid, Mohammad TP Chemical technology A statistical approach with D-optimal design was used to optimize the process parameters for polycaprolactone (PCL) synthesis. The variables selected were temperature (50°C-110°C), time (1-7 h), mixing speed (50-500 rpm) and monomer/solvent ratio (1:1-1:6). Molecular weight was chosen as response and was determined using matrix-assisted laser desorption/ionization time of flight (MALDI TOF). Using the D-optimal method in design of experiments, the interactions between parameters and responses were analysed and validated. The results show a good agreement with a minimum error between the actual and predicted values. Wiley 2018 Article PeerReviewed Pakalapati, Harshini and Arumugasamy, Senthil Kumar and Jewaratnam, Jegalakshimi and Wong, Yong Jie and Khalid, Mohammad (2018) Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology. Biopolymers, 109 (12). e23240. ISSN 0006-3525 https://doi.org/10.1002/bip.23240 doi:10.1002/bip.23240
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Pakalapati, Harshini
Arumugasamy, Senthil Kumar
Jewaratnam, Jegalakshimi
Wong, Yong Jie
Khalid, Mohammad
Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology
description A statistical approach with D-optimal design was used to optimize the process parameters for polycaprolactone (PCL) synthesis. The variables selected were temperature (50°C-110°C), time (1-7 h), mixing speed (50-500 rpm) and monomer/solvent ratio (1:1-1:6). Molecular weight was chosen as response and was determined using matrix-assisted laser desorption/ionization time of flight (MALDI TOF). Using the D-optimal method in design of experiments, the interactions between parameters and responses were analysed and validated. The results show a good agreement with a minimum error between the actual and predicted values.
format Article
author Pakalapati, Harshini
Arumugasamy, Senthil Kumar
Jewaratnam, Jegalakshimi
Wong, Yong Jie
Khalid, Mohammad
author_facet Pakalapati, Harshini
Arumugasamy, Senthil Kumar
Jewaratnam, Jegalakshimi
Wong, Yong Jie
Khalid, Mohammad
author_sort Pakalapati, Harshini
title Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology
title_short Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology
title_full Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology
title_fullStr Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology
title_full_unstemmed Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology
title_sort parametric optimization of polycaprolactone synthesis catalysed by candida antarctica lipase b using response surface methodology
publisher Wiley
publishDate 2018
url http://eprints.um.edu.my/21049/
https://doi.org/10.1002/bip.23240
_version_ 1643691451797733376
score 13.211869

Similar Items