Epithelial-to-mesenchymal transition (EMT) causing acquired resistance to afatinib in a patient with epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma

• Main Authors: Poh, Mau Ern, Liam, Chong Kin, Rajadurai, Pathmanathan, Chai, Chee Shee
• Format: Article
• Published: AME Publishing Company 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/21020/; https://doi.org/10.21037/jtd.2018.06.122

We report the first case of epithelial-to-mesenchymal transition (EMT) as the cause of acquired resistance to the second-generation EGFR-tyrosine kinase inhibitor (TKI), afatinib in a patient with advanced non-small cell lung cancer (NSCLC) harboring a sensitizing EGFR mutation. Patients with EGFRmu...