Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways
The innate immune system serves as the first line of defense to protect the host from pathogen infection. As a first step, the pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs), such as non-self DNA derived from pathogens, and damage-associated molecular p...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Article |
Published: |
Begell House
2018
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/20640/ https://doi.org/10.1615/CritRevImmunol.2018026540 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.um.eprints.20640 |
---|---|
record_format |
eprints |
spelling |
my.um.eprints.206402019-03-11T04:28:59Z http://eprints.um.edu.my/20640/ Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways Sok, Sophia Ping Meow Ori, Daisuke Nagoor, Noor Hasima Kawai, Taro Q Science (General) QH Natural history The innate immune system serves as the first line of defense to protect the host from pathogen infection. As a first step, the pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs), such as non-self DNA derived from pathogens, and damage-associated molecular patterns (DAMPs), such as self DNA released from damaged or injured cells. Sensing of such DNAs elicits innate immune responses through the production of type I interferons (IFNs) and proinflammatory cytokines resulting from the activation of interferon regulatory factor 3 (IRF3) and nuclear factor kappa B (NF-κB), respectively. These cytokines are key players in interlinking innate and adaptive immune responses. However, defects in DNA sensors and their signaling cascades lead to dysregulation of immune responses, autoimmune diseases, and cancer progression. Here we provide an update on DNA signaling pathways in response to pathogen infection and cell injury, and on the roles of regulators in governing the immune system and maintaining host homeostasis. We also discuss the evasion of immunosurveillance by pathogens. Begell House 2018 Article PeerReviewed Sok, Sophia Ping Meow and Ori, Daisuke and Nagoor, Noor Hasima and Kawai, Taro (2018) Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways. Critical Reviews in Immunology, 38 (4). pp. 279-301. ISSN 1040-8401 https://doi.org/10.1615/CritRevImmunol.2018026540 doi:10.1615/CritRevImmunol.2018026540 |
institution |
Universiti Malaya |
building |
UM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaya |
content_source |
UM Research Repository |
url_provider |
http://eprints.um.edu.my/ |
topic |
Q Science (General) QH Natural history |
spellingShingle |
Q Science (General) QH Natural history Sok, Sophia Ping Meow Ori, Daisuke Nagoor, Noor Hasima Kawai, Taro Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways |
description |
The innate immune system serves as the first line of defense to protect the host from pathogen infection. As a first step, the pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs), such as non-self DNA derived from pathogens, and damage-associated molecular patterns (DAMPs), such as self DNA released from damaged or injured cells. Sensing of such DNAs elicits innate immune responses through the production of type I interferons (IFNs) and proinflammatory cytokines resulting from the activation of interferon regulatory factor 3 (IRF3) and nuclear factor kappa B (NF-κB), respectively. These cytokines are key players in interlinking innate and adaptive immune responses. However, defects in DNA sensors and their signaling cascades lead to dysregulation of immune responses, autoimmune diseases, and cancer progression. Here we provide an update on DNA signaling pathways in response to pathogen infection and cell injury, and on the roles of regulators in governing the immune system and maintaining host homeostasis. We also discuss the evasion of immunosurveillance by pathogens. |
format |
Article |
author |
Sok, Sophia Ping Meow Ori, Daisuke Nagoor, Noor Hasima Kawai, Taro |
author_facet |
Sok, Sophia Ping Meow Ori, Daisuke Nagoor, Noor Hasima Kawai, Taro |
author_sort |
Sok, Sophia Ping Meow |
title |
Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways |
title_short |
Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways |
title_full |
Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways |
title_fullStr |
Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways |
title_full_unstemmed |
Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways |
title_sort |
sensing self and non-self dna by innate immune receptors and their signaling pathways |
publisher |
Begell House |
publishDate |
2018 |
url |
http://eprints.um.edu.my/20640/ https://doi.org/10.1615/CritRevImmunol.2018026540 |
_version_ |
1643691337026895872 |
score |
13.18916 |