1 `-Acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression

• Main Authors: Sok, Sophia P. M., Ori, Daisuke, Wada, Ayana, Okude, Haruna, Kawasaki, Takumi, Momota, Masatoshi, Nagoor, Noor Hasima, Kawai, Taro
• Format: Article
• Published: Oxford University Press 2021
• Subjects: Q Science (General); S Agriculture (General); T Technology (General)
• Online Access: http://eprints.um.edu.my/33913/

The nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing (NLRP) 3 inflammasome is a multiprotein complex that triggers Caspase-1-mediated IL-1 beta production and pyroptosis, and its dysregulation is associated with the pathogenesis of inflammatory diseases. 1...