Cycloartane triterpenoid (23R, 24E)-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both β-catenin and c-Raf–MEK1–ERK signaling axis

• Main Authors: Kaneda, Toshio, Matsumoto, Misaki, Sotozono, Yayoi, Fukami, Satoshi, Nugroho, Alfarius Eko, Hirasawa, Yusuke, A. Hadi, A. Hamid, Morita, Hiroshi
• Format: Article
• Published: Springer Verlag (Germany) 2019
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/20058/; https://doi.org/10.1007/s11418-018-1233-7

We recently reported that (23R, 24E)-23-acetoxymangiferonic acid (23R-AMA), a cycloartane triterpenoid isolated by activity-guided separation from a methanol extract of Garcinia sp. bark, inhibited melanin production via inhibition of tyrosinase (TYR) expression in the B16-F10 melanoma cell line. Si...