Designed antiviral ankyrin – A computational approach to combat HIV-1 via intracellular pathway by targeting the viral capsid of HIV-1

• Main Authors: Karim, Hana Atiqah Abdul, Rungrotmongkol, Thanyada, Zain, Sharifuddin Md, Abd Rahman, Noorsaadah, Tayapiwattana, Chatchai, Lee, Vannajan Sanghiran
• Format: Article
• Published: Elsevier 2019
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/20056/; https://doi.org/10.1016/j.molliq.2018.12.030

Scaffold known as designed ankyrin repeat proteins (DARPins) have been utilized by scientists extensively in protein binding, as they acquire remarkable binding properties. Trimodular ankyrin repeat protein (Ank1D4) is a potential macromolecular and antiviral intracellular inhibitor that aims the N-...