Advanced glycation end products-related modulation of cathepsin L and NF-κB signalling effectors in retinal pigment epithelium lead to augmented response to TNFα

• Main Authors: Sharif, Umar, Mahmud, Nur Musfirah, Kay, Paul, Yang, Yit C., Harding, Simon Peter, Grierson, Ian, Kamalden, Tengku Ain, Jackson, Malcolm J., Paraoan, Luminita
• Format: Article
• Published: Wiley Open Access 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/19995/; https://doi.org/10.1111/jcmm.13944

The retinal pigment epithelium (RPE) plays a central role in neuroretinal homoeostasis throughout life. Altered proteolysis and inflammatory processes involving RPE contribute to the pathophysiology of age-related macular degeneration (AMD), but the link between these remains elusive. We report for...