Petroselinum crispumhas antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells
BACKGROUND: Petroselinum crispum (English parsley) is a common herb of the Apiaceae family that is cultivated throughout the world and is widely used as a seasoning condiment. Studies have shown its potential as a medicinal herb. In this study, P. crispum leaf and stem extracts were evaluated for th...
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| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Wiley
2015
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/19599/ http://dx.doi.org/10.1002/jsfa.7078 |
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| Summary: | BACKGROUND: Petroselinum crispum (English parsley) is a common herb of the Apiaceae family that is cultivated throughout the world and is widely used as a seasoning condiment. Studies have shown its potential as a medicinal herb. In this study, P. crispum leaf and stem extracts were evaluated for their antioxidant properties, protection against DNA damage in normal 3T3-L1 cells, and the inhibition of proliferation and migration of the MCF-7 cells. RESULTS: The dichloromethane extract of P. crispum exhibited the highest phenolic content (42.31 ± 0.50 mg GAE g-1) and ferric reducing ability (0.360 ± 0.009 mmol g-1) of the various extractions performed. The extract showed DPPH radical scavenging activity with an IC50 value of 3310.0 ± 80.5 μg mL-1. Mouse fibroblasts (3T3-L1) pre-treated with 400 μg mL-1 of the extract showed 50.9% protection against H2O2-induced DNA damage, suggesting its potential in cancer prevention. The extract (300 μg mL-1) inhibited H2O2-induced MCF-7 cell migration by 41% ± 4%. As cell migration is necessary for metastasis of cancer cells, inhibition of migration is an indication of protection against metastasis. CONCLUSION: Petroselinum crispum has health-promoting properties with the potential to prevent oxidative stress-related diseases and can be developed into functional food. |
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