Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.

• Main Authors: Yap, V.A., Loong, B.J., Ting, K.N., Loh, S.H.S., Yong, Kien Thai, Low, Yun Yee, Kam, Toh Seok, Lim, K.H.
• Format: Article
• Published: Elsevier 2015
• Subjects: Q Science (General); QD Chemistry; QH Natural history; R Medicine
• Online Access: http://eprints.um.edu.my/19394/; http://dx.doi.org/10.1016/j.phytochem.2014.10.032

Hispidacine, an 8,4′-oxyneolignan featuring incorporation of an unusual 2-hydroxyethylamine moiety at C-7, and hispiloscine, a phenanthroindolizidine alkaloid, were isolated from the stem-bark and leaves of the Malaysian Ficus hispida Linn. Their structures were established by spectroscopic analysis...