Staff View: Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.

Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.

Hispidacine, an 8,4′-oxyneolignan featuring incorporation of an unusual 2-hydroxyethylamine moiety at C-7, and hispiloscine, a phenanthroindolizidine alkaloid, were isolated from the stem-bark and leaves of the Malaysian Ficus hispida Linn. Their structures were established by spectroscopic analysis...

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Main Authors:	Yap, V.A., Loong, B.J., Ting, K.N., Loh, S.H.S., Yong, Kien Thai, Low, Yun Yee, Kam, Toh Seok, Lim, K.H.
Format:	Article
Published:	Elsevier 2015
Subjects:	Q Science (General) QD Chemistry QH Natural history R Medicine
Online Access:	http://eprints.um.edu.my/19394/ http://dx.doi.org/10.1016/j.phytochem.2014.10.032
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id	my.um.eprints.19394
record_format	eprints
spelling	my.um.eprints.193942021-03-22T03:36:01Z http://eprints.um.edu.my/19394/ Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn. Yap, V.A. Loong, B.J. Ting, K.N. Loh, S.H.S. Yong, Kien Thai Low, Yun Yee Kam, Toh Seok Lim, K.H. Q Science (General) QD Chemistry QH Natural history R Medicine Hispidacine, an 8,4′-oxyneolignan featuring incorporation of an unusual 2-hydroxyethylamine moiety at C-7, and hispiloscine, a phenanthroindolizidine alkaloid, were isolated from the stem-bark and leaves of the Malaysian Ficus hispida Linn. Their structures were established by spectroscopic analysis. Hispidacine induced a moderate vasorelaxant activity in rat isolated aorta, while hispiloscine showed appreciable antiproliferative activities against MDA-MB-231, MCF-7, A549, HCT-116 and MRC-5 cell lines. Elsevier 2015 Article PeerReviewed Yap, V.A. and Loong, B.J. and Ting, K.N. and Loh, S.H.S. and Yong, Kien Thai and Low, Yun Yee and Kam, Toh Seok and Lim, K.H. (2015) Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn. Phytochemistry, 109. pp. 96-102. ISSN 0031-9422 http://dx.doi.org/10.1016/j.phytochem.2014.10.032 doi:10.1016/j.phytochem.2014.10.032
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) QD Chemistry QH Natural history R Medicine
spellingShingle	Q Science (General) QD Chemistry QH Natural history R Medicine Yap, V.A. Loong, B.J. Ting, K.N. Loh, S.H.S. Yong, Kien Thai Low, Yun Yee Kam, Toh Seok Lim, K.H. Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.
description	Hispidacine, an 8,4′-oxyneolignan featuring incorporation of an unusual 2-hydroxyethylamine moiety at C-7, and hispiloscine, a phenanthroindolizidine alkaloid, were isolated from the stem-bark and leaves of the Malaysian Ficus hispida Linn. Their structures were established by spectroscopic analysis. Hispidacine induced a moderate vasorelaxant activity in rat isolated aorta, while hispiloscine showed appreciable antiproliferative activities against MDA-MB-231, MCF-7, A549, HCT-116 and MRC-5 cell lines.
format	Article
author	Yap, V.A. Loong, B.J. Ting, K.N. Loh, S.H.S. Yong, Kien Thai Low, Yun Yee Kam, Toh Seok Lim, K.H.
author_facet	Yap, V.A. Loong, B.J. Ting, K.N. Loh, S.H.S. Yong, Kien Thai Low, Yun Yee Kam, Toh Seok Lim, K.H.
author_sort	Yap, V.A.
title	Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.
title_short	Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.
title_full	Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.
title_fullStr	Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.
title_full_unstemmed	Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.
title_sort	hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from ficus hispida linn.
publisher	Elsevier
publishDate	2015
url	http://eprints.um.edu.my/19394/ http://dx.doi.org/10.1016/j.phytochem.2014.10.032
_version_	1695531081037512704
score	13.214268

Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.

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