Renal targeting potential of a polymeric drug carrier, poly-L-glutamic acid, in normal and diabetic rats

• Main Authors: Chai, H.J., Kiew, L.V., Chin, Y., Norazit, A., Noor, S.M., Lo, Y.L., Looi, C.Y., Lau, Y.S., Lim, T.M., Wong, W.F., Abdullah, N.A., Sattar, M.Z.A., Johns, E.J., Chik, Z., Chung, L.Y.
• Format: Article
• Published: Dove Medical Press 2017
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/19216/; http://dx.doi.org/10.2147/IJN.S111284

Background and purpose: Poly-l-glutamic acid (PG) has been used widely as a carrier to deliver anticancer chemotherapeutics. This study evaluates PG as a selective renal drug carrier. Experimental approach: 3H-deoxycytidine-labeled PGs (17 or 41 kDa) and 3H-deoxycytidine were administered intravenou...