CD24, CD44 and EpCAM enrich for tumour-initiating cells in a newly established patient-derived xenograft of nasopharyngeal carcinoma

• Main Authors: Hoe, S.L.L., Tan, L.P., Abdul Aziz, N., Liew, K., Teow, S.Y., Abdul Razak, F.R., Chin, Y.M., Mohamed Shahrehan, N.A., Chu, T.L., Mohd Kornain, N.K., Peh, S.C., Koay, C.E., Lo, K.W., Ahmad, M., Ng, C.C., Khoo, A.S.B.
• Format: Article
• Published: Nature Publishing Group 2017
• Subjects: Q Science (General); QH Natural history; R Medicine
• Online Access: http://eprints.um.edu.my/19169/; http://dx.doi.org/10.1038/s41598-017-12045-8

Subpopulations of nasopharyngeal carcinoma (NPC) contain cells with differential tumourigenic properties. Our study evaluates the tumourigenic potential of CD24, CD44, EpCAM and combination of EpCAM/CD44 cells in NPC. CD44br and EpCAMbr cells enriched for higher S-phase cell content, faster-growing...