CD24, CD44 and EpCAM enrich for tumour-initiating cells in a newly established patient-derived xenograft of nasopharyngeal carcinoma

• Main Authors: Hoe, Susan Ling Ling, Tan, Lu Ping, Abdul Aziz, Norazlin, Liew, Kitson, Teow, Sin Yeang *, Abdul Razak, Fazlyn Reeny, Chin, Yoon Ming, Mohamed Shahrehan, Nurul Ashikin, Chu, Tai Lin, Mohd Kornain, Noor Kaslina, Peh, Suat Cheng *, Koay, Cheng Eng, Lo, Kwok-Wai, Ahmad, Munirah, Ng, Ching-Ching, Khoo, Alan Soo Beng
• Format: Article
• Language: English
• Published: Nature Publishing Group 2017
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.sunway.edu.my/830/1/Ronald%20Teow%20CD24%20CD44.pdf; http://eprints.sunway.edu.my/830/; http://doi.org/10.1038/s41598-017-12045-8

Subpopulations of nasopharyngeal carcinoma (NPC) contain cells with differential tumourigenic properties. Our study evaluates the tumourigenic potential of CD24, CD44, EpCAM and combination of EpCAM/CD44 cells in NPC. CD44br and EpCAMbr cells enriched for higher S-phase cell content, fastergrowing t...