HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution

• Main Authors: Yap, S.H., Abdullah, N.K., McStea, M., Takayama, K., Chong, M.L., Crisci, E., Larsson, M., Azwa, I., Kamarulzaman, A., Leong, K.H., Woo, Y.L., Rajasuriar, R.
• Format: Article
• Published: Public Library of Science 2017
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/18960/; http://dx.doi.org/10.1371/journal.pone.0186000

Background: Co-infections with human herpesvirus (HHV) have been associated with residual chronic inflammation in antiretroviral (ART)-treated human immunodeficiency virus (HIV)-infected individuals. However, the role of HHV in modulating the tryptophan-kynurenine pathway and clinical outcomes in HI...