Hyaluronidase Inhibitory Activity of Pentacylic Triterpenoids from Prismatomeris tetrandra (Roxb.) K. Schum: Isolation, Synthesis and QSAR Study

• Main Authors: Abdullah, N.H., Thomas, Noel Francis, Sivasothy, Y., Lee, Vannajan Sanghiran, Liew, Sook Yee, Noorbatcha, I.A., Awang, Khalijah
• Format: Article
• Language: English
• Published: MDPI 2016
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/17998/1/ijms-17-00143.pdf; http://eprints.um.edu.my/17998/; http://dx.doi.org/10.3390/ijms17020143

The mammalian hyaluronidase degrades hyaluronic acid by the cleavage of the β-1,4-glycosidic bond furnishing a tetrasaccharide molecule as the main product which is a highly angiogenic and potent inducer of inflammatory cytokines. Ursolic acid 1, isolated from Prismatomeris tetrandra, was identified...