Evaluation of pharmacokinetics and blood-brain barrier permeability of mitragynine using in vivo microdialysis technique

• Main Authors: Kong, W.M., Mohamed, Z., Alshawsh, M.A., Chik, Z.
• Format: Article
• Published: Elsevier 2017
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/17613/; http://dx.doi.org/10.1016/j.jpba.2017.05.020

A microdialysis system coupled with a sensitive ultra-fast liquid chromatography–mass spectrometry (UFLC-MS) method was developed for the pharmacokinetic analysis of mitragynine in rat blood and striatum. Mitragynine is an active alkaloid of Mitragyna speciosa and has been proposed to be used for op...