Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba.

• Main Authors: Qureshi, Ahmad Kaleem, Mukhtar, Mat Ropi, Hirasawa, Yusuke, Hosoya, Takahiro, Nugroho, Alfarius Eko, Morita, Hiroshi, Shirota, Osamu, Mohamad, Khalit, A. Hadi, A. Hamid, Litaudon, M., Awang, Khalijah
• Format: Article
• Published: Pharmaceutical Society of Japan 2011
• Subjects: RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/175/; http://www.jstage.jst.go.jp/article/cpb/59/2/59_291/_article

Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of...