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Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba.

Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of...

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Bibliographic Details
Main Authors: Qureshi, Ahmad Kaleem, Mukhtar, Mat Ropi, Hirasawa, Yusuke, Hosoya, Takahiro, Nugroho, Alfarius Eko, Morita, Hiroshi, Shirota, Osamu, Mohamad, Khalit, A. Hadi, A. Hamid, Litaudon, M., Awang, Khalijah
Format: Article
Published: Pharmaceutical Society of Japan 2011
Subjects:
RS Pharmacy and materia medica
Online Access:http://eprints.um.edu.my/175/
http://www.jstage.jst.go.jp/article/cpb/59/2/59_291/_article
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Summary:Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.

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