Anti-Inflammatory Activity of Calophyllum inophyllum Fruits Extracts

• Main Author: Ilham, Zul
• Format: Article
• Language: English
• Published: Elsevier 2014
• Subjects: QD Chemistry; QH301 Biology; TP Chemical technology
• Online Access: http://eprints.um.edu.my/16777/1/MZ2014-Calophyllum.pdf; http://eprints.um.edu.my/16777/; http://dx.doi.org/10.1016/j.proche.2014.12.031

In the present work, we are reporting the isolation. characterisation and bioactvity of inophyllums, xanthones and other compounds found in the fruits of Callophyllum inophyllum. In-vitro assays demonstrated that the crude extract at concentration of 50 Pg/ml inhibited 77% and 88% cyclooxygenase and lipooxygenase activities, respectively, indicating its potential as antiinflamatory agent. Phytochemical studies was also conducted on the fruits. Inophyllum A, inophyllum C, inophyllum E, calophylloide, calophynic acid, 11,12-anhydroinophyllum A, 1,7-dihydroxy-6-methoxyxanthone, potocatechuic acid, gallic acid, n-nonacosane, E-sitosterol and sitosterol-3-O-E-D-glucopyranoside were isolated and idetified. On the HPLC chromatogram, at least 18 compounds can be detected.