Anti-Inflammatory Activity of Calophyllum inophyllum Fruits Extracts
In the present work, we are reporting the isolation. characterisation and bioactvity of inophyllums, xanthones and other compounds found in the fruits of Callophyllum inophyllum. In-vitro assays demonstrated that the crude extract at concentration of 50 Pg/ml inhibited 77% and 88% cyclooxygenase and...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014
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| Online Access: | http://eprints.um.edu.my/16777/1/MZ2014-Calophyllum.pdf http://eprints.um.edu.my/16777/ http://dx.doi.org/10.1016/j.proche.2014.12.031 |
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| Summary: | In the present work, we are reporting the isolation. characterisation and bioactvity of inophyllums, xanthones and other compounds found in the fruits of Callophyllum inophyllum. In-vitro assays demonstrated that the crude extract at concentration of 50 Pg/ml inhibited 77% and 88% cyclooxygenase and lipooxygenase activities, respectively, indicating its potential as antiinflamatory
agent. Phytochemical studies was also conducted on the fruits. Inophyllum A, inophyllum C, inophyllum E,
calophylloide, calophynic acid, 11,12-anhydroinophyllum A, 1,7-dihydroxy-6-methoxyxanthone, potocatechuic acid, gallic acid, n-nonacosane, E-sitosterol and sitosterol-3-O-E-D-glucopyranoside were isolated and idetified. On the HPLC chromatogram, at least 18 compounds can be detected. |
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