Anti-Tuberculosis natural products: synthesis and biological evaluation of pyridoacridine alkaloids related to ascididemin
There is an urgent need for novel therapeutics possessing new modes of action to treat tuberculosis (TB) infections. In this study we report on the synthesis and biological evaluation of a series of pyrido[2,3,4-kI] acridin-6-one alkaloids related to the anti-TB (MIC 0.35 mu M) but cytotoxic (IC(50)...
Saved in:
Main Authors: | Appleton, D.R., Pearce, A.N., Copp, B.R. |
---|---|
Format: | Article |
Published: |
Elsevier
2010
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/12696/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Synthesis and characterization of polymeric derivatives of isoniazid as anti-tuberculosis drugs
by: Sivakamy Sunthiram
Published: (2014) -
Iron(III) and zinc(II) metal alkaloid complexes: Synthesis, characterization and biological activities
by: Naureen, Bushra, et al.
Published: (2021) -
Development of an alkaloid–pyrone annulation: synthesis of
pleiomaltinine
by: Kam, T.S., et al.
Published: (2012) -
Alkaloids from alphonsea elliptica barks and their biological activities
by: Obaid, Ahmed Kareem, et al.
Published: (2018) -
Alkaloids from the genus Dehaasia: phytochemistry and biological activities
by: Salleh, W. M. N. H. W., et al.
Published: (2017)