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Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius

Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showe...

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Main Authors: Deguchi, J., Shoji, T., Nugroho, A.E., Hirasawa, Y., Hosoya, T., Shirota, O., Awang, Khalijah, Hadi, A.H.A., Morita, H.
Format: Article
Published: American Chemical Society 2010
Subjects:
Q Science (General)
Online Access:http://eprints.um.edu.my/12249/
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spelling my.um.eprints.122492019-03-01T08:51:35Z http://eprints.um.edu.my/12249/ Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius Deguchi, J. Shoji, T. Nugroho, A.E. Hirasawa, Y. Hosoya, T. Shirota, O. Awang, Khalijah Hadi, A.H.A. Morita, H. Q Science (General) Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently. American Chemical Society 2010 Article PeerReviewed Deguchi, J. and Shoji, T. and Nugroho, A.E. and Hirasawa, Y. and Hosoya, T. and Shirota, O. and Awang, Khalijah and Hadi, A.H.A. and Morita, H. (2010) Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius. Journal of Natural Products-Copublished with the Am. Soc. of Pharmacognosy, 73 (10). pp. 1727-1729.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
spellingShingle Q Science (General)
Deguchi, J.
Shoji, T.
Nugroho, A.E.
Hirasawa, Y.
Hosoya, T.
Shirota, O.
Awang, Khalijah
Hadi, A.H.A.
Morita, H.
Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius
description Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently.
format Article
author Deguchi, J.
Shoji, T.
Nugroho, A.E.
Hirasawa, Y.
Hosoya, T.
Shirota, O.
Awang, Khalijah
Hadi, A.H.A.
Morita, H.
author_facet Deguchi, J.
Shoji, T.
Nugroho, A.E.
Hirasawa, Y.
Hosoya, T.
Shirota, O.
Awang, Khalijah
Hadi, A.H.A.
Morita, H.
author_sort Deguchi, J.
title Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius
title_short Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius
title_full Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius
title_fullStr Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius
title_full_unstemmed Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius
title_sort eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius
publisher American Chemical Society
publishDate 2010
url http://eprints.um.edu.my/12249/
_version_ 1643689257378775040
score 13.214268

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