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Cytotoxic and antioxidant Compoundsfrom the stem bark of goniothalamus tapisoides Mat Salleh

Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds...

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Bibliographic Details
Main Author: Leong, K.H.
Format: Article
Language:English
Published: Springer Verlag (Germany) 2012
Subjects:
Q Science (General)
QD Chemistry
QH301 Biology
QK Botany
R Medicine
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RV Botanic, Thomsonian, and eclectic medicine
Online Access:http://eprints.um.edu.my/10005/1/Cytotoxic_and_antioxidant_compounds_from_the_stem_bark_of_Goniothalamus_tapisoides_Mat_Salleh.pdf
http://eprints.um.edu.my/10005/
http://www.mdpi.com/1420-3049/18/1/128
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Summary:Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM.

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