Unraveling of the genetic polymorphism for ultra-rapid metabolism of phenytoin / Fazleen Haslinda Mohd Hatta , Prof Madya Dr The Lay Kek , Prof Dr Mohd Zaki Salleh

• Main Authors: Mohd Hatta, Fazleen Haslinda, Teh, Lay Kek, Salleh, Mohd Zaki
• Format: Research Reports
• Language: English
• Published: Research Management Institute , Universiti Teknologi MARA 2010
• Subjects: Drugs and their actions
• Online Access: https://ir.uitm.edu.my/id/eprint/6429/1/LP_FAZLEEN%20HASLINDA%20MOHD%20HATTA%2010_24.pdf; https://ir.uitm.edu.my/id/eprint/6429/

The frequency of functionally important mutations and alleles of genes coding for CYP2C9 metabolizing enzymes shows a wide ethnic variation. However, little is known of the frequency distribution of the minor allelic variants that could explain other metabolic capacity. Methods: Using polymerase...