Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek

• Main Authors: Salleh, Mohd Zaki, Teh, Lay Kek
• Format: Research Reports
• Language: English
• Published: Research Management Institute (RMI) 2010
• Subjects: Genetic polymorphisms; Transplantation of organs, tissues, etc.
• Online Access: https://ir.uitm.edu.my/id/eprint/9751/1/LP_MOHD%20ZAKI%20SALLEH%20RMI%2010_24.pdf; https://ir.uitm.edu.my/id/eprint/9751/

Tacrolimus is an immunosuppressant commonly used for long term in transplant patients to prevent organ rejection. Its use faces clinical challenges in achieving optimum dose for all patients. There are wide variation in doses of tacrolimus required for patients resulting in different drug levels and...