The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar

• Main Author: Che Omar, Ruhil Nadirah
• Format: Thesis
• Language: English
• Published: 2024
• Subjects: DNA. Deoxyribonucleic acids; Genetics
• Online Access: https://ir.uitm.edu.my/id/eprint/107234/1/107234.pdf; https://ir.uitm.edu.my/id/eprint/107234/

There is an issue of inconsistencies of working with hepatocytes obtained from different human liver donors in drug metabolism studies. CRISPR type II (Cas9) is the most recent development in biotechnology that could potentially resolve this limitation by precise and efficient alteration of genetic...