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The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar

There is an issue of inconsistencies of working with hepatocytes obtained from different human liver donors in drug metabolism studies. CRISPR type II (Cas9) is the most recent development in biotechnology that could potentially resolve this limitation by precise and efficient alteration of genetic...

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Main Author: Che Omar, Ruhil Nadirah
Format: Thesis
Language:English
Published: 2024
Subjects:
DNA. Deoxyribonucleic acids
Genetics
Online Access:https://ir.uitm.edu.my/id/eprint/107234/1/107234.pdf
https://ir.uitm.edu.my/id/eprint/107234/
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id my.uitm.ir.107234
record_format eprints
spelling my.uitm.ir.1072342024-12-04T08:29:45Z https://ir.uitm.edu.my/id/eprint/107234/ The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar Che Omar, Ruhil Nadirah DNA. Deoxyribonucleic acids Genetics There is an issue of inconsistencies of working with hepatocytes obtained from different human liver donors in drug metabolism studies. CRISPR type II (Cas9) is the most recent development in biotechnology that could potentially resolve this limitation by precise and efficient alteration of genetic sequences. It works in almost any kind of living cells and became possible after the recent discovery of genome editing technologies. Clustered regularly interspaced short palindromic repeats (CRISPR) – associated nucleus (Cas), allows for small changes to a known, targeted location on the DNA sequence efficiently at a faster rate, and ease of use. 2024 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/107234/1/107234.pdf The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar. (2024) Masters thesis, thesis, Universiti Teknologi MARA (UiTM). <http://terminalib.uitm.edu.my/107234.pdf>
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic DNA. Deoxyribonucleic acids
Genetics
spellingShingle DNA. Deoxyribonucleic acids
Genetics
Che Omar, Ruhil Nadirah
The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
description There is an issue of inconsistencies of working with hepatocytes obtained from different human liver donors in drug metabolism studies. CRISPR type II (Cas9) is the most recent development in biotechnology that could potentially resolve this limitation by precise and efficient alteration of genetic sequences. It works in almost any kind of living cells and became possible after the recent discovery of genome editing technologies. Clustered regularly interspaced short palindromic repeats (CRISPR) – associated nucleus (Cas), allows for small changes to a known, targeted location on the DNA sequence efficiently at a faster rate, and ease of use.
format Thesis
author Che Omar, Ruhil Nadirah
author_facet Che Omar, Ruhil Nadirah
author_sort Che Omar, Ruhil Nadirah
title The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
title_short The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
title_full The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
title_fullStr The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
title_full_unstemmed The generation of CYP2C9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / Ruhil Nadirah Che Omar
title_sort generation of cyp2c9 knocked-down human hepatocyte library: a utilization of crispr/cas9 system / ruhil nadirah che omar
publishDate 2024
url https://ir.uitm.edu.my/id/eprint/107234/1/107234.pdf
https://ir.uitm.edu.my/id/eprint/107234/
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score 13.222552

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