A novel gene-activated matrix composed of PEI/plasmid-BMP2 complexes and hydroxyapatite/chitosan-microspheres promotes bone regeneration

• Main Authors: Ding, Ruyuan, Liu, Yajun, Cheng, Dawei, Yang, Gang, Wu, Wenjing, Du, Haoran, Jin, Xin, Chen, Yihan, Wang, Yuanyin, Heng, Boon Chin *, Xu, Jianguang
• Format: Article
• Published: Springer 2022
• Subjects: QH Natural history; QR Microbiology; RD Surgery
• Online Access: http://eprints.sunway.edu.my/3114/; https://link.springer.com/article/10.1007/s12274-022-4292-8

The incorporation of pro-osteogenic growth factors into bone graft materials to enhance bone regeneration is a key research area within the field of bone tissue engineering and regenerative medicine. However, growth factors directly incorporated in protein form are easily degraded, and have a limite...