New synthetic phenylquinazoline derivatives induce apoptosis by targeting the pro-survival members of the BCL-2 family

• Main Authors: Simon, Samson Eugin, Usman, Ahmed *, Saad, Syed Muhammad, Ayaz, Anwar *, Khan, Khalid Mohammed, Tan, Ee Wern *, Tan, Kuan Onn *
• Format: Article
• Published: Elsevier 2022
• Subjects: QH Natural history; RC Internal medicine; RM Therapeutics. Pharmacology
• Online Access: http://eprints.sunway.edu.my/3113/; https://doi.org/10.1016/j.bmcl.2022.128731

Chemo-resistant cancer cells acquire robust growth potential through cell signaling mechanisms such as the down-regulation of tumor suppressors and the up-regulation of pro-survival proteins, respectively. To overcome chemo-resistance of cancer, small molecule drugs that interact with the cell signa...