Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy
Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-vinifer...
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my.sunway.eprints.31082024-08-13T05:24:06Z http://eprints.sunway.edu.my/3108/ Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy Fuloria, Shivkanya Sekar, Mahendran Farrah Syazaba, Khattulanuar Gan, Siew Hua Nur Najihah, Izzati Mat Rani Ravi, Subban Vetriselvan, Subramaniyan Jeyabalan, Srikanth Begum, M Yasmin Chidambaram, Kumarappan Kathiresan, V Sathasivam Sher Zaman, Safi Wu, Yuan Seng * Rusli, Bin Nordin Mohammad Nazmul, Hasan Mazia Vinoth, Kumarasamy Lum, Pei Teng Fuloria, Neeraj Kumar QP Physiology RM Therapeutics. Pharmacology Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-viniferin (ε-viniferin), gamma-viniferin (γ-viniferin), R-viniferin (vitisin A), and R2-viniferin (vitisin B). All of these forms exhibit a range of important biological activities and, therefore, have several possible applications in clinical research and future drug development. In this review, we present a comprehensive literature search on the chemistry and biosynthesis of and the diverse studies conducted on viniferin, especially with regards to its anti-inflammatory, antipsoriasis, antidiabetic, antiplasmodic, anticancer, anti-angiogenic, antioxidant, anti-melanogenic, neurodegenerative effects, antiviral, antimicrobial, antifungal, antidiarrhea, anti-obesity and anthelminthic activities. In addition to highlighting its important chemical and biological activities, coherent and environmentally acceptable methods for establishing vinferin on a large scale are highlighted to allow the development of further research that can help to exploit its properties and develop new phyto-pharmaceuticals. Overall, viniferin and its derivatives have the potential to be the most effective nutritional supplement and supplementary medication, especially as a therapeutic approach. More researchers will be aware of viniferin as a pharmaceutical drug as a consequence of this review, and they will be encouraged to investigate viniferin and its derivatives as pharmaceutical drugs to prevent future health catastrophes caused by a variety of serious illnesses. MDPI 2022 Article PeerReviewed text en cc_by_4 http://eprints.sunway.edu.my/3108/1/Wu%20Yuan%20Seng_Chemistry%20biosynthesis%20and%20pharmacology%20of%20viniferin.pdf Fuloria, Shivkanya and Sekar, Mahendran and Farrah Syazaba, Khattulanuar and Gan, Siew Hua and Nur Najihah, Izzati Mat Rani and Ravi, Subban and Vetriselvan, Subramaniyan and Jeyabalan, Srikanth and Begum, M Yasmin and Chidambaram, Kumarappan and Kathiresan, V Sathasivam and Sher Zaman, Safi and Wu, Yuan Seng * and Rusli, Bin Nordin and Mohammad Nazmul, Hasan Mazia and Vinoth, Kumarasamy and Lum, Pei Teng and Fuloria, Neeraj Kumar (2022) Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy. Molecules, 27 (16). ISSN 1420-3049 https://doi.org/10.3390/molecules27165072 10.3390/molecules27165072 |
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QP Physiology RM Therapeutics. Pharmacology Fuloria, Shivkanya Sekar, Mahendran Farrah Syazaba, Khattulanuar Gan, Siew Hua Nur Najihah, Izzati Mat Rani Ravi, Subban Vetriselvan, Subramaniyan Jeyabalan, Srikanth Begum, M Yasmin Chidambaram, Kumarappan Kathiresan, V Sathasivam Sher Zaman, Safi Wu, Yuan Seng * Rusli, Bin Nordin Mohammad Nazmul, Hasan Mazia Vinoth, Kumarasamy Lum, Pei Teng Fuloria, Neeraj Kumar Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy |
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Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-viniferin (ε-viniferin), gamma-viniferin (γ-viniferin), R-viniferin (vitisin A), and R2-viniferin (vitisin B). All of these forms exhibit a range of important biological activities and, therefore, have several possible applications in clinical research and future drug development. In this review, we present a comprehensive literature search on the chemistry and biosynthesis of and the diverse studies conducted on viniferin, especially with regards to its anti-inflammatory, antipsoriasis, antidiabetic, antiplasmodic, anticancer, anti-angiogenic, antioxidant, anti-melanogenic, neurodegenerative effects, antiviral, antimicrobial, antifungal, antidiarrhea, anti-obesity and anthelminthic activities. In addition to highlighting its important chemical and biological activities, coherent and environmentally acceptable methods for establishing vinferin on a large scale are highlighted to allow the development of further research that can help to exploit its properties and develop new phyto-pharmaceuticals. Overall, viniferin and its derivatives have the potential to be the most effective nutritional supplement and supplementary medication, especially as a therapeutic approach. More researchers will be aware of viniferin as a pharmaceutical drug as a consequence of this review, and they will be encouraged to investigate viniferin and its derivatives as pharmaceutical drugs to prevent future health catastrophes caused by a variety of serious illnesses. |
format |
Article |
author |
Fuloria, Shivkanya Sekar, Mahendran Farrah Syazaba, Khattulanuar Gan, Siew Hua Nur Najihah, Izzati Mat Rani Ravi, Subban Vetriselvan, Subramaniyan Jeyabalan, Srikanth Begum, M Yasmin Chidambaram, Kumarappan Kathiresan, V Sathasivam Sher Zaman, Safi Wu, Yuan Seng * Rusli, Bin Nordin Mohammad Nazmul, Hasan Mazia Vinoth, Kumarasamy Lum, Pei Teng Fuloria, Neeraj Kumar |
author_facet |
Fuloria, Shivkanya Sekar, Mahendran Farrah Syazaba, Khattulanuar Gan, Siew Hua Nur Najihah, Izzati Mat Rani Ravi, Subban Vetriselvan, Subramaniyan Jeyabalan, Srikanth Begum, M Yasmin Chidambaram, Kumarappan Kathiresan, V Sathasivam Sher Zaman, Safi Wu, Yuan Seng * Rusli, Bin Nordin Mohammad Nazmul, Hasan Mazia Vinoth, Kumarasamy Lum, Pei Teng Fuloria, Neeraj Kumar |
author_sort |
Fuloria, Shivkanya |
title |
Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy |
title_short |
Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy |
title_full |
Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy |
title_fullStr |
Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy |
title_full_unstemmed |
Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy |
title_sort |
chemistry, biosynthesis and pharmacology of viniferin: potential resveratrol-derived molecules for new drug discovery, development and therapy |
publisher |
MDPI |
publishDate |
2022 |
url |
http://eprints.sunway.edu.my/3108/1/Wu%20Yuan%20Seng_Chemistry%20biosynthesis%20and%20pharmacology%20of%20viniferin.pdf http://eprints.sunway.edu.my/3108/ https://doi.org/10.3390/molecules27165072 |
_version_ |
1808975642874609664 |
score |
13.19449 |