Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy

• Main Authors: Fuloria, Shivkanya, Sekar, Mahendran, Farrah Syazaba, Khattulanuar, Gan, Siew Hua, Nur Najihah, Izzati Mat Rani, Ravi, Subban, Vetriselvan, Subramaniyan, Jeyabalan, Srikanth, Begum, M Yasmin, Chidambaram, Kumarappan, Kathiresan, V Sathasivam, Sher Zaman, Safi, Wu, Yuan Seng *, Rusli, Bin Nordin, Mohammad Nazmul, Hasan Mazia, Vinoth, Kumarasamy, Lum, Pei Teng, Fuloria, Neeraj Kumar
• Format: Article
• Language: English
• Published: MDPI 2022
• Subjects: QP Physiology; RM Therapeutics. Pharmacology
• Online Access: http://eprints.sunway.edu.my/3108/1/Wu%20Yuan%20Seng_Chemistry%20biosynthesis%20and%20pharmacology%20of%20viniferin.pdf; http://eprints.sunway.edu.my/3108/; https://doi.org/10.3390/molecules27165072

Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-viniferin (ε-viniferin), gamma-viniferin (γ-viniferin), R-viniferin (vitisin A), and R2-viniferin (vitisin B). All of these forms exhibit a range of important biological activities and, therefore, have several possible applications in clinical research and future drug development. In this review, we present a comprehensive literature search on the chemistry and biosynthesis of and the diverse studies conducted on viniferin, especially with regards to its anti-inflammatory, antipsoriasis, antidiabetic, antiplasmodic, anticancer, anti-angiogenic, antioxidant, anti-melanogenic, neurodegenerative effects, antiviral, antimicrobial, antifungal, antidiarrhea, anti-obesity and anthelminthic activities. In addition to highlighting its important chemical and biological activities, coherent and environmentally acceptable methods for establishing vinferin on a large scale are highlighted to allow the development of further research that can help to exploit its properties and develop new phyto-pharmaceuticals. Overall, viniferin and its derivatives have the potential to be the most effective nutritional supplement and supplementary medication, especially as a therapeutic approach. More researchers will be aware of viniferin as a pharmaceutical drug as a consequence of this review, and they will be encouraged to investigate viniferin and its derivatives as pharmaceutical drugs to prevent future health catastrophes caused by a variety of serious illnesses.