Flumazenil Pretreatment Reduces Mefenamic Acid-Induced Central Nervous System Toxicity in Mice

• Main Authors: Jarrar, Qais, Ayoub, Rami, Jarrar, Yazun, Aburass, Hadeel, Goh, Khang Wen, Ardianto, Chrismawan, Long, Chiau Ming *, Moshawih, Said, Alfaqih, Hussain
• Format: Article
• Published: IMR Press 2023
• Subjects: QL Zoology; QM Human anatomy; QP Physiology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2890/; https://www.imrpress.com/journal/JIN/22/4/10.31083/j.jin2204104

Background: Mefenamic acid (MFA), a common analgesic, causes central nervous system (CNS) toxicity at high doses with a proposed activity on the Gamma-aminobutyric acid (GABA) system. However, it remains unknown whether flumazenil (FMZ), a GABA type A receptor (GABAAR) antagonist, can reverse MFA to...