Is Proteolytic Cleavage Essential for the Enhanced Activity of Hydra Pore-Forming Toxin, HALT-4?

• Main Authors: Yap, Wei Yuen *, Hwang, Jung Shan *
• Format: Article
• Language: English
• Published: MDPI 2023
• Subjects: QH Natural history; QR Microbiology
• Online Access: http://eprints.sunway.edu.my/2718/1/Hwang%20Jung%20Shan_Is%20proteolytic%20cleavage%20essential.pdf; http://eprints.sunway.edu.my/2718/; https://doi.org/10.3390/toxins15060396

Hydra actinoporin-like toxin 4 (HALT-4) differs from other actinoporins due to its N-terminal propart that contains approximately 103 additional residues. Within this region, we identified five dibasic residues and assumed that, when cleaved, they could potentially exhibit HALT-4's cytolytic ac...