Optimization of a Luteolin-Loaded TPGS/Poloxamer 407 Nanomicelle: The Effects of Copolymers, Hydration Temperature and Duration, and Freezing Temperature on Encapsulation Efficiency, Particle Size, and Solubility

• Main Authors: Muhammad Redza, Fahmi Mod Razif, Chan, Siok Yee, Riyanto, Teguh Widodo, Chew, Yik-Ling, Masriana, Hassan, Shairyzah, Ahmad Hisham, Shamima, Abdul Rahman, Long, Chiau Ming *, Tan, Ching Siang, Lee, Siew-Keah, Liew, Kai Bin
• Format: Article
• Language: English
• Published: MDPI 2023
• Subjects: QC Physics; QD Chemistry; RC Internal medicine; RS Pharmacy and materia medica
• Online Access: http://eprints.sunway.edu.my/2713/1/Long%20Chiau%20Ming_Optimization%20of%20a%20Luteolin-loaded%20TPGS.pdf; http://eprints.sunway.edu.my/2713/; https://doi.org/10.3390/cancers15143741

Background: Luteolin is a flavonoid compound that has been widely studied for its various anti-cancer properties and sensitization to multidrug-resistant cells. However, the limited solubility and bioavailability of Lut hindered its potential clinical use. Theoretically, the combination of this comp...