Molecular mechanistic pathways underlying the anticancer therapeutic efficiency of romidepsin

• Main Authors: El Omari, Nasreddine, Lee, Learn-Han, Bakrim, Saad, Makeen, Hafiz A, Alhazmi, Hassan A, Mohan, Syam, Khalid, Asaad, Long, Chiau Ming *, Bouyahya, Abdelhakim
• Format: Article
• Language: English
• Published: Elsevier
• Subjects: QH Natural history; QP Physiology; RC Internal medicine; RS Pharmacy and materia medica
• Online Access: http://eprints.sunway.edu.my/2710/1/Long%20Chiau%20Ming_Molecular%20mechanistic%20pathways%20underlying%20the%20anticancer.pdf; http://eprints.sunway.edu.my/2710/; https://doi.org/10.1016/j.biopha.2023.114774

Romidepsin, also known as NSC630176, FR901228, FK-228, FR-901228, depsipeptide, or Istodax®, is a natural molecule produced by the Chromobacterium violaceum bacterium that has been approved for its anti-cancer effect. This compound is a selective histone deacetylase (HDAC) inhibitor, which modifies...