Natural bioactive compounds targeting DNA methyltransferase enzymes in cancer: Mechanisms insights and efficiencies

• Main Authors: Aanniz, Tarik, Bouyahya, Abdelhakim, Balahbib, Abdelaali, El Kadri, Kawtar, Khalid, Asaad, Makeen, Hafiz A, Alhazmi, Hassan A, El Omari, Nasreddine, Zaid, Younes, Wong, Rebecca Shin-Yee *, Yeo, Chien Ing *, Goh, Bey Hing *, Bakrim, Saad
• Format: Article
• Language: English
• Published: Elsevier 2024
• Subjects: QH Natural history; QP Physiology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2548/1/Rebecca%20Wong%20Shin%20Yee_Natural%20bioactive%20compounds%20targeting%20DNA_Chemico%20Biological%20Interactions.pdf; http://eprints.sunway.edu.my/2548/; https://doi.org/10.1016/j.cbi.2024.110907

The regulation of gene expression is fundamental to health and life and is essentially carried out at the promoter region of the DNA of each gene. Depending on the molecular context, this region may be accessible or non-accessible (possibility of integration of RNA polymerase or not at this region)....