Carotenoids: Role in Neurodegenerative Diseases Remediation

• Main Authors: Gandla, Kumaraswamy, Babu, Ancha Kishore, Unnisa, Aziz, Sharma, Indu, Singh, Laliteshwar Pratap, Haque, Mahammad Akiful, Dashputre, Neelam Laxman, Baig, Shahajan, Siddiqui, Falak A., Khandaker, Mayeen Uddin *, Almujally, Abdullah, Tamam, Nissren, Sulieman,, Khan, Sharuk L., Emran, Talha Bin
• Format: Article
• Language: English
• Published: MDPI 2023
• Subjects: QP Physiology; RB Pathology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2266/1/50.pdf; http://eprints.sunway.edu.my/2266/; https://doi.org/10.3390/ brainsci13030457

Numerous factors can contribute to the development of neurodegenerative disorders (NDs), such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis. Oxidative stress (OS), a fairly common ND symptom, can be caused by more reactive oxygen species being made. In addition, the pathological state of NDs, which includes a high number of protein aggregates, could make chronic inflammation worse by activating microglia. Carotenoids, often known as “CTs”, are pigments that exist naturally and play a vital role in the prevention of several brain illnesses. CTs are organic pigments with major significance in ND prevention. More than 600 CTs have been discovered in nature, and they may be found in a wide variety of creatures. Different forms of CTs are responsible for the red, yellow, and orange pigments seen in many animals and plants. Because of their unique structure, CTs exhibit a wide range of bioactive effects, such as anti-inflammatory and antioxidant effects. The preventive effects of CTs have led researchers to find a strong correlation between CT levels in the body and the avoidance and treatment of several ailments, including NDs. To further understand the connection between OS, neuroinflammation, and NDs, a literature review has been compiled. In addition, we have focused on the anti-inflammatory and antioxidant properties of CTs for the treatment and management of NDs.