Cadmium(II) compounds of the bis-cyanoethyl derivative (LCX) of Me8[14]aneC (LC): characterization and antibacterial studies

• Main Authors: Chakraborty, Avijit, Rabi, Saswata, Dey, Lucky, Palit, Debashis, Dey, Benu Kumar, Tiekink, Edward R. T. *, Roy, T. G.
• Format: Article
• Language: English
• Published: Elsevier 2022
• Subjects: QD Chemistry
• Online Access: http://eprints.sunway.edu.my/2100/1/heliyon%208%202022%20e09678.pdf; http://eprints.sunway.edu.my/2100/; https://doi.org/10.1016/j.heliyon.2022.e09678

The isomeric ligand LC, a saturated analogue of 2,9-C-meso-Me8[14]diene, on reflux with excess acrylonitrile afforded 1,8-N-pendant cyanoethyl derivative LCX. Interaction of LCX with cadmium(II) perchlorate, nitrate, acetate, and chloride salts produced six coordinated octahedral compounds, [Cd(LCX) (ClO4)2]∙2H2O, [Cd(LCX) (NO3)2], [Cd(LCX) (CH3COO)2], and [Cd(LCX)Cl2], respectively. Further, axial substitution reactions between [Cd(LCX) (ClO4)2]∙2H2O and KI, KBr, KCl, KSCN, and NaNO2 in a 1:2 ratio yielded six coordinated octahedral compounds, [Cd(LCX)I2]∙H2O, [Cd(LCX)Br2]∙2H2O, [Cd(LCX)Cl(ClO4)]∙2H2O, [Cd(LCX) (NCS)2]∙H2O, and [Cd(LCX) (NO2) (ClO4)]∙2H2O, respectively. All of the newly prepared compounds have been characterized by analytical, spectroscopic, molar conductivity, and magnetochemical data. The crystal structure of the ligand LCX was determined by x-ray crystallography which showed the 14-membered ring to adopt an extended chair conformation. Antibacterial activities of the newly formed cadmium(II) complexes against selected bacteria showed these to exhibit moderate and selective activity with 1-4 and 8 exhibiting greatest potency against the gram negative bacterium Salmonella typhi, and 5, 6, and 7 against the gram positive bacterium Bacillus wiedmannii.