Synthesis, structural characterisation and theoretical studies of a novel pyridazine derivative: Investigations of anti-inflammatory activity and inhibition of α-glucosidase

• Main Authors: Zaoui, Younes, Ramli, Youssef, Tan, Sang Loon *, Tiekink, Edward R. T. *, Chemlal, L., Mague, Joel T., Taoufik, Jamal, Faouzi, M. E. A., Ansar, M'hammed
• Format: Article
• Language: English
• Published: Elsevier 2021
• Subjects: QD Chemistry
• Online Access: http://eprints.sunway.edu.my/1652/1/Tiekink%20Synthesis%20structural_accepted.pdf; http://eprints.sunway.edu.my/1652/; http://doi.org/10.1016/j.molstruc.2021.130177

X-ray crystallography on pyridazine 1 (ethyl 2-(3-methyl-4-(4-methylbenzyl)-6-oxopyridazin1(6H)-yl)acetate) shows the planar pyridazinyl ring to exhibit significant delocalisation of πelectron density over the constituent atoms and to be substituted with oxo, methyl, (4- methylphenyl)methyl and N-b...