Design, synthesis, and biological evaluation of new 6,N2-diaryl-1,3,5-triazine-2,4-diamines as anticancer agents selectively targeting triple negative breast cancer cells

• Main Authors: Ahmad Junaid,, Lim, Felicia Phei Lin, Tiekink, Edward R. T. *, Dolzhenko, Anton V
• Format: Article
• Language: English
• Published: Royal Society of Chemistry 2020
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://eprints.sunway.edu.my/1329/1/Tiekink%20RSC%20Adv%202020%2010%2025517.pdf; http://eprints.sunway.edu.my/1329/; http://doi.org/10.1039/d0ra04970k

New 6,N2-diaryl-1,3,5-triazine-2,4-diamines were designed using the 3D-QSAR model developed earlier. These compounds were prepared and their antiproliferative activity was evaluated against three breast cancer cell lines (MDA-MB231, SKBR-3 and MCF-7) and non-cancerous MCF-10A epithelial breast cell...